Targeting dihydroceramide desaturase 1 (Des1): Syntheses of ceramide analogues with a rigid scaffold, inhibitory assays, and AlphaFold2-assisted structural insights reveal cyclopropenone PR280 as a potent inhibitor-Reference-Cited by-同舟云学术

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Targeting dihydroceramide desaturase 1 (Des1): Syntheses of ceramide analogues with a rigid scaffold, inhibitory assays, and AlphaFold2-assisted structural insights reveal cyclopropenone PR280 as a potent inhibitor

Published:2024-04 Issue: Volume:145 Page:107233
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Rivero Pablo,Ivanova Varbina,Barril Xavier,Casampere Mireia,Casas Josefina,Fabriàs Gemma,Díaz Yolanda,Matheu M. Isabel

Funder

European Social Fund Plus

Agencia Estatal de Investigación

Generalitat de Catalunya Agencia de Gestio d'Ajuts Universitaris i de Recerca

Universitat Rovira i Virgili

España Ministerio de Ciencia Innovación y Universidades

Ministerio de Ciencia e Innovación

Generalitat de Catalunya

European Regional Development Fund

Publisher

Elsevier BV

Reference68 articles.

1. Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide;Michel;J. Biol. Chem.,1997

2. Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena;Fabriàs;Prog. Lipid Res.,2012

3. Dihydroceramide delta(4) desaturase initiates substrate oxidation at C-4;Savile;J. Am. Chem. Soc.,2001

4. Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases;Lachkar;Am. J. Physiol. Endocrinol. Metab.,2021

5. Dihydroceramides: From Bit Players to Lead Actors;Siddique;J. Biol. Chem.,2015

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