Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment-Reference-Cited by-同舟云学术

Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment

Published:2022-03 Issue: Volume:120 Page:105646
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Elgiushy Hossam R.,Mohamed Sameh H.,Taha Heba,Sawaf Hussein,Hassan Zeinab,Abou-Taleb Nageh A.,El-labbad Eman M.,Hassan Ashraf S.,Abouzid Khaled A.M.,Hammad Sherif F.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference56 articles.

1. The challenge of drug resistance in cancer treatment: a current overview;Nikolaou;Clinical and Experimental Metastasis.,2018

2. Current Directions and Trends of Cancer Chemotherapy: An Overview of the Recently Approved Small-Molecules Anticancer Drugs in the Past Decade;Soudan;Am J Biomed Sci & Res.,2021

3. Trends in kinase drug discovery: targets, indications and inhibitor design;Attwood;Nat Rev Drug Discov,2021

4. M. Szumilak, A. Wiktorowska-Owczarek, A. Stanczak, Hybrid Drugs—A Strategy for Overcoming Anticancer Drug Resistance?, Molecules 2021, Vol. 26, Page 2601. 26 (2021) 2601. doi:10.3390/MOLECULES26092601.

5. Potential Anticancer Properties and Mechanisms of Action of Formononetin;Jiang;BioMed Research International.,2019

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unveiling the promise of pyrimidine-modified CDK inhibitors in cancer treatment;Bioorganic Chemistry;2024-08

2. Exploring the Potential Biological Activities of Pyrazole-Based Schiff Bases as Anti-Diabetic, Anti-Alzheimer’s, Anti-Inflammatory, and Cytotoxic Agents: In Vitro Studies with Computational Predictions;Pharmaceuticals;2024-05-17

3. In vitro biological studies and computational prediction-based analyses of pyrazolo[1,5-a]pyrimidine derivatives;RSC Advances;2024

4. Design, Synthesis and Anticancer Evaluation of New 1-allyl-4-oxo-6-(3,4,5- trimethoxyphenyl)-1,4-dihydropyrimidine-5-carbonitrile Bearing Pyrazole Moieties;Current Organic Synthesis;2023-12

5. Synthesis, In Vitro Biological Investigation, and In Silico Analysis of Pyrazole-Based Derivatives as Multi-target Agents;Egyptian Journal of Chemistry;2023-05-03