Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer’s disease

Author:

Yang Xia,Qiang Xiaoming,Li Yan,Luo Li,Xu Rui,Zheng Yunxiaozhu,Cao Zhongcheng,Tan Zhenghuai,Deng Yong

Funder

Chinese National Natural Science Foundation

Research Fund for the Doctoral Program of Higher Education

National Science and Technology Major Project on “Key New Drug Creation and Manufacturing Program”

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference36 articles.

1. Mechanisms of disease Alzheimer’s disease;Querfurth;New Engl. J. Med.,2010

2. P. Martin, C. Adelina, K. Martin, G. Maëlenn, K. Maria, World Alzheimer report 2016: improving healthcare for people living with dementia: coverage, quality and costs now and in the future (2016) 1–140.

3. Alzheimer’s disease;Scheltens;Lancet,2016

4. Untangling amyloid-β, tau, and metals in Alzheimer’s disease;Savelieff;ACS Chem. Biol.,2013

5. Alzheimer’s disease: from pathology to therapeutic approaches;Jakob-Roetne;Angew. Chem. Int. Ed. Engl.,2009

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