A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3′,5′-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A-Reference-Cited by-同舟云学术

A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3′,5′-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A

Published:2008-06 Issue:3 Volume:36 Page:141-147
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Hung Su H.,Liu Andy H.,Pixley Robin A.,Francis Penelope,Williams LaTeeka D.,Matsko Christopher M.,Barnes Karine D.,Sivendran Sharmila,Colman Roberta F.,Colman Robert W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference32 articles.

1. Insights from Affinity Labeling into Nucleotide- and Coenzyme-Dependent Enzyme Catalysis and Regulation

2. Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling

3. Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use

4. Overview of PDEs and Their Regulation

5. Crystal Structures of Phosphodiesterases and Implications on Substrate Specificity and Inhibitor Selectivity

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1. Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiesterase3 (PDE3): A target for heart failure and platelet aggregation;Bioorganic & Medicinal Chemistry Letters;2012-09

2. Phosphodiesterase 3 mediates cross-talk between the protein kinase- and cGMP- dependent pathways and cyclic AMP metabolism;Postępy Higieny i Medycyny Doświadczalnej;2012-07-20

3. Increased adhesive properties of platelets in sickle cell disease: roles for αIIbβ3-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity;British Journal of Haematology;2010-04