Structure-based drug design, synthesis, and biological evaluation of novel 1,3,5-triazine or pyrimidine derivatives containing benzoyl hydrazine moiety as PI3Kα selective inhibitors-Reference-Cited by-同舟云学术

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Structure-based drug design, synthesis, and biological evaluation of novel 1,3,5-triazine or pyrimidine derivatives containing benzoyl hydrazine moiety as PI3Kα selective inhibitors

Published:2023-11 Issue: Volume:140 Page:106738
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Fu Siyu,Liu Jiuyu,Li Chunting,Wei Jiakuan,Yue Hao,Yang Ao,Wang Kang,Wu Yongshuo,Hou Yunlei,Zhao Yanfang

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference38 articles.

1. Chemically targeting the PI3K family;Knight;Biochem Soc Trans.,2007

2. PI3K isoforms in cell signalling and vesicle trafficking;Bilanges;Nat Rev Mol Cell Biol.,2019

3. Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours;Xu;Cell Biosci.,2020

4. Targeting PI3K in cancer: mechanisms and advances in clinical trials;Yang;Mol Cancer.,2019

5. The PI3K pathway in human disease;Fruman;Cell.,2017

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1. Synthesis and Antitumor Activity Evaluation of Novel Echinatin Derivatives with a 1,3,4-Oxadiazole Moiety;International Journal of Molecular Sciences;2024-02-13

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