Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice

Author:

Alshammari Aya Hasan,Masuo Yusuke,Yoshino Shotaro,Yamashita Reiya,Ishimoto TakahiroORCID,Fujita Ken-ichi,Kato YukioORCID

Funder

Japan Society for the Promotion of Science

Publisher

Elsevier BV

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference17 articles.

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2. Recent progress in in vivo phenotyping technologies for better prediction of transporter-mediated drug-drug interactions;Maeda;Drug Metabol Pharmacokinet,2020

3. Breast cancer resistance protein (Bcrp/abcg2) is a major determinant of sulfasalazine absorption and elimination in the mouse;Zaher;Mol Pharm,2006

4. Deletion of Abcg2 has differential effects on excretion and pharmacokinetics of probe substrates in rats;Huang;J Pharmacol Exp Therapeut,2012

5. The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine;van Herwaarden;Cancer Res,2003

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