Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human
Author:
Publisher
Elsevier BV
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference40 articles.
1. Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964–1985);Prentis;Br J Clin Pharmacol,1988
2. Can the pharmaceutical industry reduce attrition rates?;Kola;Nat Rev Drug Discov,2004
3. Principles of early drug discovery;Hughes;Br J Pharmacol,2011
4. In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery;Masimirembwa;Comb Chem High Throughput Screen,2001
5. Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans;Akabane;Xenobiotica,2011
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