Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide-Reference-Cited by-同舟云学术

Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide

Published:2007-02 Issue:2 Volume:458 Page:167-174
ISSN:0003-9861
Container-title:Archives of Biochemistry and Biophysics
language:en
Short-container-title:Archives of Biochemistry and Biophysics

Author:

Sun Ling,Chen Chong S.,Waxman David J.,Liu Hong,Halpert James R.,Kumar Santosh

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Biophysics

Reference34 articles.

1. Cytochromes P450 and metabolism of xenobiotics

2. Analysis of Mammalian Cytochrome P450 Structure and Function by Site-Directed Mutagenesis

3. Activation of the Anticancer Prodrugs Cyclophosphamide and Ifosfamide: Identification of Cytochrome P450 2B Enzymes and Site-Specific Mutants with Improved Enzyme Kinetics

4. 2,2‘,3,3‘,6,6‘-Hexachlorobiphenyl Hydroxylation by Active Site Mutants of Cytochrome P450 2B1 and 2B11

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