Mechanism of α-subunit selectivity of benzodiazepine pharmacology at γ-aminobutyric acid type A receptors

Author:

Wingrove Peter B,Safo Patrick,Wheat Lola,Thompson Sally A,Wafford Keith A,Whiting Paul J

Publisher

Elsevier BV

Subject

Pharmacology

Reference38 articles.

1. Two tyrosine residues on the α subunit are crucial for benzodiazepine binding and allosteric modulation of γ-aminobutyric acidA receptors;Amin;Mol. Pharmacol.,1997

2. International Union of Pharmacology: XV. Subtypes of γ-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function;Barnard;Pharmacol. Rev.,1998

3. Pharmacology of recombinant γ-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated α-subunits;Benson;FEBS Lett.,1998

4. θ, a novel γ-aminobutyric acid type A receptor subunit;Bonnert;Proc. Natl. Acad. Sci. U.S.A.,1999

5. Photoaffinity labelling of the benzodiazepine receptor compromises the recognition site but not its effector mechanism;Brown;J. Neurochem.,1984

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