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The establishment of humanized IL-4/IL-4RA mouse model by gene editing and efficacy evaluation

  • Published:2020-09 Issue:5 Volume:225 Page:151998
  • ISSN:0171-2985
  • Container-title:Immunobiology
  • language:en
  • Short-container-title:Immunobiology

Author:

Yan Peili,Su Youhong,Shang Chengzhang,Zhou Xiaofei,Yang Yi,An Wenqian,An Wenlin,Yu Changyuan,Wang Shihui

Funder

National Key Research and Development Project

National Natural Science Foundation of China

Shenzhen Science and Technology Project

National Mega-project for Innovative Drugs

Publisher

Elsevier BV

Subject

Hematology,Immunology,Immunology and Allergy

Reference29 articles.

1. Endotypes of allergic diseases and asthma: an important step in building blocks for the future of precision medicine;Agache;Allergol. Int.,2016

2. Polymorphisms in IL4 and IL4RA confer susceptibility to asthma;Amirzargar;J. Investig. Allergol. Clin. Immunol.,2009

3. Prospects for monoclonal antibody therapy in pediatric asthma;August;Cur Allergy Asthma R,2018

4. Can Guideline-defined Asthma Control Be Achieved?;Bateman;Am. J. Respir. Crit. Care Med.,2004

5. IL-4 and IL-13 dual antagonism a promising approach to the dilemma of generating effective asthma biotherapeutics;Borish;Am. J. Respir. Crit. Care Med.,2010

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