Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process

Author:

Singh Ravendra,Román-Ospino Andrés D.,Romañach Rodolfo J.,Ierapetritou Marianthi,Ramachandran Rohit

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference17 articles.

1. An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process: an integrated approach;Boukouvala;Comput. Chem. Eng.,2012

2. Direct measurement of the bulk density of cohesive particulatematerials by a quasicontinuous in-line weighing method;Davies,2011

3. FDA, PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004, http://www.fda.gov/downloads/Drugs/Guidances/ucm070305.pdf (accessed 19.09.15.).

4. FDA, Guidance for industry, Q8 (R2) pharmaceutical development, 2007, http://www.fda.gov/downloads/Drugs/Guidances/ucm073507.pdf (accessed 19.09.15.).

5. Handling uncertainty in the establishment of a design space for the manufacture of a pharmaceutical product;García-Muñoz;Comput. Chem. Eng.,2010

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