The effects of polyvinyl alcohol on the in vitro stability and delivery of spray-dried protein particles from surfactant-free HFA 134a-based pressurised metered dose inhalers

Author:

Liao Yong-Hong,Brown Marc B.,Jones Stuart A.,Nazir Tahir,Martin Gary P.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference23 articles.

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2. The lung as a route for systemic delivery of therapeutic peptides and proteins;Agu;Respir. Res.,2001

3. Factors affecting short-term and long-term stabilities of proteins;Arakawa;Adv. Drug. Deliv. Rev.,1993

4. Carpenter, J. F., Izutsu, K., Randolph, T. W., 1999. Freezing and drying-induced perturbations of protein structure and mechanisms of protein protection by stabilizing additives. In: Rey, L., May, J. C. (Eds.), Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products. New York, pp. 123–160.

5. Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation;Chi;Pharm. Res.,2003

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