Characterization, efficacy, pharmacokinetics, and biodistribution of 5kDa mPEG modified tetrameric canine uricase variant

Author:

Zhang Chun,Fan Kai,Luo Hua,Ma Xuefeng,Liu Riyong,Yang Li,Hu Chunlan,Chen Zhenmin,Min Zhiqiang,Wei Dongzhi

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference38 articles.

1. Resolution of tophi with intravenous PEG-uricase in refractory gout;Baraf;Arthritis Rheum.,2005

2. Pegloticase, a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout;Biggers;Curr. Opin. Investig. Drugs,2008

3. Biopharmaceutical properties of uricase conjugated to neutral and amphiphilic polymers;Caliceti;Bioconjug. Chem.,1999

4. Immunological properties of uricase conjugated to neutral soluble polymers;Caliceti;Bioconjug. Chem.,2001

5. Properties of two urate oxidases modified by the covalent attachment of poly(ethylene glycol);Chen;Biochim. Biophys. Acta,1981

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