Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study

Author:

Melichar Bohuslav,Adenis Antoine,Lockhart A Craig,Bennouna Jaafar,Dees E Claire,Kayaleh Omar,Obermannova Radka,DeMichele Angela,Zatloukal Petr,Zhang Bin,Ullmann Claudio Dansky,Schusterbauer Claudia

Publisher

Elsevier BV

Subject

Oncology

Reference32 articles.

1. Aurora kinases;Bolanos-Garcia;Int J Biochem Cell Biol,2005

2. Aurora A kinase (AURKA) in normal and pathological cell division;Nikonova;Cell Mol Life Sci,2013

3. A novel aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma;Gorgun;Blood,2010

4. Frequent overexpression of aurora kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions;Dar;Cancer,2008

5. Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast;Hoque;Cancer Epidemiol Biomarkers Prev,2003

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