The dopamine D3 receptor antagonist, (+)-S14297, blocks the cataleptic properties of haloperidol in rats

Author:

Millan Mark J,Gressier Huguette,Brocco Mauricette

Publisher

Elsevier BV

Subject

Pharmacology

Reference8 articles.

1. Accili, D., Fishburn, C.S., Drago, J., Steiner, H., Lachowicz, J.E., Park, B.-H., Gauda, E.B., Lee, E.J., Cool, M.H., Sibley, D.R., Gerfen, C.R., Westphal, H., Fuchs, S., 1996. A targeted mutation of the dopamine D3 receptor gene is associated with hyperactivity in mice. Proc. Natl. Acad. Sci. USA 93, 1945–1949.

2. Baik, H., Picetti, R., Salardi, A., Thiriet, G., Dierich, A., Depaulis, A., Le Meur, M., Borrelli, 1995. Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature 377, 424–428.

3. Gobert, A., Rivet, J.-M., Audinot, V., Cistarelli, L., Spedding, M., Vian, J., Peglion, J.-L., Millan, M.J., 1995. Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: II. Both D2 and `silent' D3 autoreceptors control synthesis and release in mesolimbic, mesocortical and nigrostriatal pathways. J. Pharmacol. Exp. Ther. 275, 899–913.

4. Lieberman, J.A., 1993. Understanding the mechanism of action of atypical antipsychotic drugs. A review of compounds in use and development. Br. J. Psychiatry 163, 7–18.

5. Millan, M.J., Peglion, J.-L., Vian, J., Rivet, J.-M., Brocco, M., Gobert, A., Newman-Tancredi, A., Dacquet, C., Bervoets, K., Girardon, S., Jacques, V., Chaput, C., Audinot, V., 1995. Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: I. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy. J. Pharmacol. Exp. Ther. 275, 885–898.

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