High affinity blockade of the HERG cardiac K+ channel by the neuroleptic pimozide

Author:

Kang Jiesheng,Wang Lin,Cai Feng,Rampe David

Publisher

Elsevier BV

Subject

Pharmacology

Reference21 articles.

1. KvLQT1 and IsK (minK) proteins associate to form the IKs cardiac potassium current;Barhanin;Nature,1996

2. Torsades de pointes and proarrhythmia;Ben-David;Lancet,1993

3. Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6);Desta;Clin. Pharmacol. Ther.,1999

4. Antipsychotic pimozide is a potent Ca2+ channel blocker in heart;Enyeart;Mol. Pharmacol.,1990

5. Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current;Fedida;Circ. Res.,1993

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