The putative «silent» 5-HT1A receptor antagonist, WAY 100635, has inverse agonist properties at cloned human 5-HT1A receptors

Author:

Cosi Cristina,Koek Wouter

Publisher

Elsevier BV

Subject

Pharmacology

Reference18 articles.

1. Effects of 5-HT1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (s)-WAY 100135, but not WAY 100635, has partial agonist properties;Assié;Eur. J. Pharmacol.,1996

2. Agonist-independent activation of Gz by the 5-hydroxytryptamine1A receptor co-expressed in Spodoptera frugiperda cells: distinguishing inverse agonists from neutral antagonists;Barr;J. Biol. Chem.,1997

3. Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions;Costa;Mol. Pharmacol.,1990

4. Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in absence of ligand;Costa;Mol. Pharmacol.,1992

5. Effector coupling mechanisms of cloned-HT1A receptor;Fargin;J. Biol.Chem.,1989

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