Comet assay evaluation of six chemicals of known genotoxic potential in rats

Author:

Hobbs Cheryl A.,Recio Leslie,Streicker Michael,Boyle Molly H.,Tanaka Jin,Shiga AtsushiORCID,Witt Kristine L.

Funder

Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (NIEHS)

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Genetics

Reference50 articles.

1. ICH, International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) S2(R1): Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use step 4 version, (2011).

2. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing;Tice;Environ. Mol. Mutagen.,2000

3. Recommendations for conducting the in vivo alkaline Comet assay. 4th International Comet Assay Workshop;Hartmann;Mutagenesis,2003

4. Fourth International Workgroup on Genotoxicity testing: results of the in vivo Comet assay workgroup;Burlinson;Mutat. Res.,2007

5. JaCVAM initiative international validation study of in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results;Uno;Mutat. Res.,2015

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