Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo

Author:

Dobrovolsky Vasily N.,Matsuda Tomonari,McKinzie Page,Miranda Jaime,Revollo Javier R.

Funder

U.S. Food and Drug Administration

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Genetics

Reference30 articles.

1. Food and Drug Administration, H.H.S., International Conference on Harmonisation; guidance on S2(R1) Genotoxicity Testing and Data Interpretation for Pharmaceuticals intended for Human Use; availability. Notice, Fed Regist, 77 (2012) 33748–33749.

2. Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity;Robison;Mutat. Res. Genet. Toxicol. Environ. Mutagen.,2021

3. Detailed review of transgenic rodent mutation assays;Lambert;Mutat. Res.,2005

4. Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing;Hoang;Proc. Natl. Acad. Sci. USA,2016

5. Detection of ultra-rare mutations by next-generation sequencing;Schmitt;Proc. Natl. Acad. Sci. USA,2012

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