How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

Author:

Kirkland David,Pfuhler Stefan,Tweats David,Aardema Marilyn,Corvi Raffaella,Darroudi Firouz,Elhajouji Azeddine,Glatt Hansruedi,Hastwell Paul,Hayashi Makoto,Kasper Peter,Kirchner Stephan,Lynch Anthony,Marzin Daniel,Maurici Daniela,Meunier Jean-Roc,Müller Lutz,Nohynek Gerhard,Parry James,Parry Elizabeth,Thybaud Veronique,Tice Ray,van Benthem Jan,Vanparys Philippe,White Paul

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Genetics

Reference40 articles.

1. Evaluation of the ability of a battery of 3 in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity;Kirkland;Mutat. Res.,2005

2. An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data. I. Identification of carcinogens using surrogate endpoints;Matthews;Regul. Toxicol. Pharmacol.,2006

3. Oxidative stress in cell culture: an under-appreciated problem?;Halliwell;FEBS Lett.,2003

4. Factors affecting the ascorbate- and phenolic-dependent generation of hydrogen peroxide in Dulbecco's modified Eagles medium;Wee;Free Radic. Res.,2003

5. L.H. Long, D. Kirkland, B. Halliwell, Different cytotoxicities of epigallocatechin gallate or ascorbate in various cell culture media due to variable rates of oxidation in the culture medium, Mutat. Res., submitted for publication.

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