The antileishmanial drug miltefosine (Impavido ® ) causes oxidation of DNA bases, apoptosis, and necrosis in mammalian cells

Author:

Castelo Branco Patrícia Valéria,Soares Rossy-Eric Pereira,de Jesus Luís Cláudio Lima,Moreira Vanessa Ribeiro,Alves Hugo José,de Castro Belfort Marta Regina,Silva Vera Lucia Maciel,Ferreira Pereira Silma Regina

Funder

Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico do Maranhão − FAPEMA

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Genetics

Reference39 articles.

1. Miltefosine-discovery of the antileishmanial activity of phospholipid derivatives;Croft;Trans. R. Soc. Trop. Med. Hyg.,2006

2. Oxidative stress in human infectious diseases—present and current knowledge about its druggability;Wrenger,2013

3. FDA. Food and Drug Administration. Briefing Document for the Anti-Infective Drugs Advisory Committee Meeting. Miltefosine (Impavido®) for the Treatment of Visceral, Mucosal and Cutaneous Leishmaniasis. (2013) NDA 204,684.

4. Miltefosine for new world cutaneous leishmaniasis;Soto;Clin. Infect. Dis.,2004

5. Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial;Machado;PloS Negl. Trop. Dis.,2010

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