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Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5a-o1: the first oxygenation step in taxol biosynthesis

  • Published:1996-06 Issue:6 Volume:3 Page:479-489
  • ISSN:1074-5521
  • Container-title:Chemistry & Biology
  • language:en
  • Short-container-title:Chemistry & Biology

Author:

Hefner Jerry,Rubenstein Steven M.,Ketchum Raymond E.B.,Gibson Donna M.,Williams Robert M.,Croteau Rodney

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference53 articles.

1. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia;Wani;J. Am. Chem. Soc.,1971

2. Current status of clinical trials with paclitaxel and docetaxel;Holmes,1995

3. Taxol: clinical results and current issues in development;Arbuck,1995

4. The chemistry of taxol;Kingston;Pharmacol. Therapeut,1991

5. The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents;Cragg;J. Nat. Prod.,1993

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