Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site

Author:

Sarafianos Stefan G.,Dasi Kalyan,Dingi Jianping,Boyer Paul L.,Hughes Stephen H.,Arnold Edward

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference68 articles.

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2. The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1;Rodgers,1995

3. Structure of unliganded HIV-1 reverse transcriptase at 2.7 Å resolution: implications of conformational changes for polymerization and inhibitionmechanisms;Hsiou;Structure,1996

4. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA;Jacobo-Molina,1993

5. Å review of HIV-1 RT structural studies and implications for drug design;Ding,1997

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