Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides

Author:

Marx Andreas,Spichty Martin,Amacker Mario,Schwitter Urs,Hübscher Ulrich,Bickle Thomas A,Maga Giovanni,Giese Bernd

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference23 articles.

1. Human immunodeficiency viruses and their replication;Luciw,1996

2. DNA replication and chemotherapy;Hübscher;Physiol. Rev.,1994

3. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor;Kohlstaedt;Science,1992

4. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA;Jacobo-Molina,1993

5. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for nucleoside analog drug resistance;Huang;Science,1998

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