Safety of biologics, lessons learnt from TGN1412

Author:

Stebbings Richard,Poole Stephen,Thorpe Robin

Publisher

Elsevier BV

Subject

Biomedical Engineering,Bioengineering,Biotechnology

Reference41 articles.

1. Topological requirements and signalling properties of T cell-activating, anti-CD28 antibody superagonists;Lühder;J Exp Med,2003

2. TGN1412 investigator's brochure. TeGenero AG, Wurzburg, Germany 2005, Accessed at http://www.circare.org/foia5/tgn1412investigatorbrochure.pdf.

3. CD28/B7 system of T cell costimulation;Lenschow;Annu Rev Immunol,1996

4. The B7 family revisited;Greenwald;Annu Rev Immunol,2005

5. CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28;Tacke;Eur J Immunol,1997

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