De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance

Author:

Veeraraghavan Jamunarani,De Angelis Carmine,Reis-Filho Jorge S.,Pascual Tomás,Prat Aleix,Rimawi Mothaffar F.,Osborne C. Kent,Schiff Rachel

Funder

NIH

Cancer Center

Breast Cancer Research Foundation

Cancer Prevention & Research Institute of Texas

The Conquer Cancer Foundation

Instituto de Salud Carlos III

Susan Komen Foundation

NIH/NCI Cancer Center

AstraZeneca and GlaxoSmithKline

GlaxoSmithKline and Genentech

Nanostring Technologies

Publisher

Elsevier BV

Subject

General Medicine,Surgery

Reference85 articles.

1. Targeting HER2 for the treatment of breast cancer;Rimawi;Annu Rev Med,2015

2. HER2: biology, detection, and clinical implications;Gutierrez;Arch Pathol Lab Med,2011

3. EGF-ERBB signalling: towards the systems level;Citri;Nat Rev Mol Cell Biol,2006

4. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial;Baselga;Lancet,2012

5. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer;Swain;N Engl J Med,2015

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