Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms (CYP2C19, ABCB1, PON1), Noncompliance, Diet, Smoking, Co-Medications (Including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function-Reference-Cited by-同舟云学术

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Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms (CYP2C19, ABCB1, PON1), Noncompliance, Diet, Smoking, Co-Medications (Including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function

Published:2013-02 Issue:8 Volume:61 Page:872-879
ISSN:0735-1097
Container-title:Journal of the American College of Cardiology
language:en
Short-container-title:Journal of the American College of Cardiology

Author:

Frelinger Andrew L.,Bhatt Deepak L.,Lee Ronald D.,Mulford Darcy J.,Wu Jingtao,Nudurupati Sai,Nigam Anu,Lampa Michael,Brooks Julie K.,Barnard Marc R.,Michelson Alan D.

Funder

Takeda Global Research & Development Center, Inc.

GLSynthesis

Lilly

Amarin

AstraZeneca

Bristol-Myers Squibb

Eisai

Ethicon

Medtronic

Sanofi Aventis

The Medicines Company

Publisher

Elsevier BV

Subject

Cardiology and Cardiovascular Medicine

Reference27 articles.

1. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update)

2. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate;Bonello;J Am Coll Cardiol,2010

3. Identification and biological activity of the active metabolite of clopidogrel;Savi;Thromb Haemost,2000

4. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite;Kazui;Drug Metab Dispos,2010

5. Paraoxonase-1 is a major determinant of clopidogrel efficacy;Bouman;Nat Med,2011

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