Benzodiazepine Use Attenuates Cortical β-Amyloid and is Not Associated with Progressive Cognitive Decline in Nondemented Elderly Adults: A Pilot Study Using F18-Florbetapir Positron Emission Tomography

Author:

Chung Jun Ku,Nakajima Shinichiro,Shinagawa Shunichiro,Plitman Eric,Chakravarty M. Mallar,Iwata Yusuke,Caravaggio Fernando,Pollock Bruce G.,Gerretsen Philip,Graff-Guerrero Ariel

Funder

ADNI

DOD ADNI

National Institute on Aging

National Institute of Biomedical Imaging and Bioengineering

Alzheimer's Association

Alzheimer's Drug Discovery Foundation

Araclon Biotech

BioClinica, Inc.

Biogen Idec Inc.

Bristol-Myers Squibb Company

Eisai Inc.

Elan Pharmaceuticals, Inc.

Eli Lilly and Company

EuroImmun

F. Hoffmann-La Roche Ltd

Genentech, Inc.

Fujirebio

GE Healthcare

IXICO Ltd.

Janssen Alzheimer Immunotherapy Research & Development, LLC.

Johnson & Johnson Pharmaceutical Research & Development LLC.

Medpace, Inc.

Merck & Co., Inc.

Meso Scale Diagnostics, LLC.

NeuroRx Research

Neurotrack Technologies

Novartis Pharmaceuticals Corporation

Pfizer Inc.

Piramal Imaging

Servier

Synarc Inc.

Takeda Pharmaceutical Company

Canadian Institutes of Health Research

CIHR

Japan Society for the Promotion of Science

Nakatomi Foundation

Ontario Gradudate Scholarship

Centre for Addiction and Mental Health CIHR

Ontario Mental Health Foundation

Publisher

Elsevier BV

Subject

Psychiatry and Mental health,Geriatrics and Gerontology

Reference40 articles.

1. Neuropsychiatric symptoms in Alzheimer disease and cognitively impaired, nondemented elderly from a community-based sample in Brazil: prevalence and relationship with dementia severity;Tatsch;Am J Geriatr Psychiatry,2006

2. Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding;Gielen;J Neurosci,2012

3. Benzodiazepine-induced amnesia and anaesthetic practice: a review;O'Boyle;Psychopharmacol Ser,1988

4. A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs;Tannenbaum;Drugs Aging,2012

5. Long-term benzodiazepine use and cognitive decline in the elderly: the Epidemiology ofVascular Aging Study;Paterniti;J Clin Psychopharmacol,2002

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