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A Two-Step Orthogonal Chromatographic Process for Purifying the Molecular Adjuvant QS-21 with High Purity and Yield

  • Published:2021-01 Issue: Volume:1635 Page:461705
  • ISSN:0021-9673
  • Container-title:Journal of Chromatography A
  • language:en
  • Short-container-title:Journal of Chromatography A

Author:

Qi Yizhi,Fox Christopher B.ORCID

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference36 articles.

1. QS-21 adjuvant;Kensil,2000

2. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex;Kensil;J. Immunol,1991

3. Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy;Jacobsen;Carbohydr. Res.,1996

4. Structure/function relationship in adjuvants from Quillaja saponaria Molina;Kensil,1992

5. Effects of QS-21 on innate and adaptive immune responses;Kensil,2006
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