Extension of the liquid chromatography/quantitative structure–property relationship method to assess the lipophilicity of neutral, acidic, basic and amphotheric drugs

Author:

Pallicer Juan M.,Calvet Carme,Port Adriana,Rosés Martí,Ràfols Clara,Bosch Elisabeth

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference51 articles.

1. Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies,2001

2. EPA Product Properties Test Guidelines, OPPTS 830.7550, Partition Coefficient (n-octanol/water), Shake Flask Method, 1996.

3. pH-Metric log P. Part 1. Difference Plots for Determining Ion-Pair Octanol-Water Partition Coefficients of Multiprotic Substances

4. pH-Metric log P. II: Refinement of Partition Coefficients and Ionization Constants of Multiprotic Substances

5. Calculation of Molecular Lipophilicity: State-of-the-Art and Comparison of LogP Methods on more than 96,000 Compounds

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