Pareto-optimal reversed-phase chromatography separation of three insulin variants with a solubility constraint

Author:

Arkell Karolina,Knutson Hans-Kristian,Frederiksen Søren S.,Breil Martin P.,Nilsson Bernt

Funder

Novo Nordisk, the Swedish Innovation Agency (Vinnova), the initiative Process Industrial IT and Automation (PiiA)

Process Industry Centre at Lund University (PIC-LU)

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference25 articles.

1. Chromatographic media for bioseparation;Jungbauer;J. Chromatogr. A,2005

2. Chromatographic techniques in the downstream processing of proteins in biotechnology;Freitag,2014

3. Determining critical process parameters and process robustness in preparative chromatography – a model-based approach;Degerman;Chem. Eng. Technol.,2009

4. Insulin purification;Mollerup,2010

5. Guidance for Industry: PAT – A Framework for Innovative Pharmaceutical Development, Manufacturing, and Quality Assurance U.S. Food and Drug Administration,2004

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