Hydrophilic interaction liquid chromatography with mass spectrometry for the separation and identification of antisense oligonucleotides impurities and nusinersen metabolites

Author:

Vosáhlová Zuzana,Kalíková KvětaORCID,Gilar MartinORCID,Szymarek Jakub,Mazurkiewicz-Bełdzińska Maria,Studzińska Sylwia

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference40 articles.

1. Opportunities and challenges for antisense oligonucleotide therapies;Kuijper;J. Inherit. Metab. Dis.,2021

2. RNA-based therapeutics: from antisense oligonucleotides to miRNAs;Bajan;Cells,2020

3. Nusinersen: a novel antisense oligonucleotide for the treatment of spinal muscular atrophy;Neil;J. Pediatr. Pharmacol. Ther.,2019

4. Rise and fall of fomivirsen, the first approved gene silencing medicine—A historical review;Bege;Acta Pharm Hung,2022

5. Nuclease resistance and antisense activity of modified oligonucleotides targeted to Ha-ras;Monia;J. Biol. Chem.,1996

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