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Protein adsorption on ion exchange resins and monoclonal antibody charge variant modulation

  • Published:2016-05 Issue: Volume:1447 Page:82-91
  • ISSN:0021-9673
  • Container-title:Journal of Chromatography A
  • language:en
  • Short-container-title:Journal of Chromatography A

Author:

Guélat Bertrand,Khalaf Rushd,Lattuada Marco,Costioli Matteo,Morbidelli Massimo

Funder

Merck (Fenil-sur-Corsier, Switzerland)

“Fondation Claude & Giuliana” (Basel, Switzerland)

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference44 articles.

1. Separation of amino acids, peptides, and proteins by ion exchange chromatography;Velickovic,2012

2. Model simulation and experimental verification of a cation-exchange IgG capture step in batch and continuous chromatography;Müller-Späth;J. Chromatogr. A,2011

3. Bioseparation in antibody manufacturing: the good, the bad and the ugly;Gottschalk;Biotechnol. Progr.,2008

4. Technology trends in antibody purification;Gagnon;J. Chromatogr. A,2012

5. Charge variants in IgG1;Khawli;mAbs,2010
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