Anti-Langmuir elution behavior of a bispecific monoclonal antibody in cation exchange chromatography: Mechanistic modeling using a pH-dependent Self-Association Steric Mass Action isotherm

Author:

Seelinger Felix,Wittkopp FelixORCID,von Hirschheydt Thomas,Frech ChristianORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference73 articles.

1. The Unreasonable Effectiveness of Equations: Advanced Modeling For Biopharmaceutical Process Development;Rolandi,2019

2. Toward in silico CMC: An industrial collaborative approach to model-based process development;Roush;Biotechnol. Bioeng.,2020

3. Recent Advances and Future Directions in Downstream Processing of Therapeutic Antibodies;Matte;Int. J. Mol. Sci.,2022

4. Steric mass-action ion exchange: Displacement profiles and induced salt gradients;Brooks;AIChE J,1992

5. Application of the Steric Mass Action formalism for modeling under high loading conditions: Part 1. Investigation of the influence of pH on the steric shielding factor;Seelinger;J. Chromatogr. A,2022

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