Kinetic performance comparison of superficially porous, fully porous and monolithic reversed-phase columns by gradient kinetic plots for the separation of protein biopharmaceuticals

Author:

Jaag SimonORCID,Wen ChunmeiORCID,Peters Benjamin,Lämmerhofer MichaelORCID

Funder

Merck KGaA

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference32 articles.

1. Fresh from the biotech pipeline—2019;Morrison;Nat. Biotechnol.,2020

2. Biopharmaceutical benchmarks 2018;Walsh;Nat. Biotechnol.,2018

3. Characterization of therapeutic antibodies and related products;Beck;Anal. Chem.,2013

4. New wide-pore superficially porous stationary phases with low hydrophobicity applied for the analysis of monoclonal antibodies;Fekete;J. Chromatogr. A,2021

5. Evaluation of additives on reversed-phase chromatography of monoclonal antibodies using a 1000 Å stationary phase;McCalley;J. Chromatogr. A,2019

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