ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons-Reference-Cited by-同舟云学术

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ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

Published:2016-03 Issue:3 Volume:6 Page:342-356
ISSN:2213-6711
Container-title:Stem Cell Reports
language:en
Short-container-title:Stem Cell Reports

Author:

Fernandes Hugo J.R.,Hartfield Elizabeth M.,Christian Helen C.,Emmanoulidou Evangelia,Zheng Ying,Booth Heather,Bogetofte Helle,Lang Charmaine,Ryan Brent J.,Sardi S. Pablo,Badger Jennifer,Vowles Jane,Evetts Samuel,Tofaris George K.,Vekrellis Kostas,Talbot Kevin,Hu Michele T.,James William,Cowley Sally A.,Wade-Martins Richard

Funder

Parkinson's UK

The Oxford Martin School

Innovative Medicines Initiative

European Union's Seventh Framework Program

EFPIA companies'

Oxford University Hospitals NHS Trust

University of Oxford

Dementias and Neurodegenerative Diseases Research Network

Fundacao para a Ciencia e Tecnologia

Wellcome Trust Career Re-Entry Fellowship

Publisher

Elsevier BV

Subject

Cell Biology,Developmental Biology,Genetics,Biochemistry

Reference47 articles.

1. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model;Alegre-Abarrategui;Hum. Mol. Genet.,2009

2. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission;Alvarez-Erviti;Neurobiol. Dis.,2011

3. Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential;Basseri;Biochem. Res. Int.,2012

4. Association of mutations in the glucocerebrosidase gene with Parkinson disease in a Korean population;Choi;Neurosci. Lett.,2012

5. The small GTPase Rab11 co-localizes with alpha-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity;Chutna;Hum. Mol. Genet.,2014

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5. GBA1MUTATIONS ALTER THE PHENOTYPE AND BEHAVIOUR OF DOPAMINERGIC NEURONS IN PARKINSON’S DISEASE, INFLUENCINGVGLUT2ANDCRYABEXPRESSION;2024-08-07

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