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Top-Down Inhibition of BMP Signaling Enables Robust Induction of hPSCs Into Neural Crest in Fully Defined, Xeno-free Conditions

  • Published:2017-10 Issue:4 Volume:9 Page:1043-1052
  • ISSN:2213-6711
  • Container-title:Stem Cell Reports
  • language:en
  • Short-container-title:Stem Cell Reports

Author:

Hackland James O.S.,Frith Tom J.R.,Thompson Oliver,Marin Navarro Ana,Garcia-Castro Martin I.,Unger Christian,Andrews Peter W.

Funder

Medical Research Council

Seventh Framework Programme

Yorkshire Cancer Research

Barncancerfonden

Publisher

Elsevier BV

Subject

Cell Biology,Developmental Biology,Genetics,Biochemistry

Reference36 articles.

1. Bmp activity establishes a gradient of positional information throughout the entire neural plate;Barth;Development,1999

2. Specification of the neural crest occurs during gastrulation and requires Pax7;Basch;Nature,2006

3. Analysis of early human neural crest development;Betters;Dev. Biol.,2010

4. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling;Chambers;Nat. Biotechnol.,2009

5. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors;Chambers;Nat. Biotechnol.,2012
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