Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model

Author:

Plaza Reyes Alvaro,Petrus-Reurer Sandra,Antonsson Liselotte,Stenfelt Sonya,Bartuma Hammurabi,Panula Sarita,Mader Theresa,Douagi Iyadh,André Helder,Hovatta Outi,Lanner Fredrik,Kvanta Anders

Funder

Swedish Research Council (VR)

Ragnar Söderberg Foundation

Swedish Foundation for Strategic Research

Stockholm County Council

Ögonfonden and Cronqvist Foundation

Knut och Alice Wallenbergs Stiftelse

Centre for Innovative Medicine

Jonasson donation

Publisher

Elsevier BV

Subject

Cell Biology,Developmental Biology,Genetics,Biochemistry

Reference27 articles.

1. Retinal pigment epithelial cells synthesize laminins, including laminin 5, and adhere to them through alpha3- and alpha6-containing integrins;Aisenbrey;Invest. Ophthalmol. Vis. Sci.,2006

2. In vivo imaging of subretinal bleb-induced outer retinal degeneration;Bartuma;Invest. Ophthalmol. Vis. Sci.,2015

3. Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex;Bhutto;Mol. Aspects Med.,2012

4. The extracellular matrix of human retinal pigment epithelial cells in vivo and its synthesis in vitro;Campochiaro;Invest. Ophthalmol. Vis. Sci.,1986

5. Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation;Carido;Invest. Ophthalmol. Vis. Sci.,2014

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