Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain-Reference-Cited by-同舟云学术

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Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain

Published:2003-06 Issue:6 Volume:73 Page:699-704
ISSN:0024-3205
Container-title:Life Sciences
language:en
Short-container-title:Life Sciences

Author:

Hruby V.J,Agnes R.S,Davis P,Ma S.-W,Lee Y.S,Vanderah T.W,Lai J,Porreca F

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference12 articles.

1. Conformational Determinants of Agonist versus Antagonist Properties of [d-Pen2,d-Pen5]Enkephalin (DPDPE) Analogs at Opioid Receptors. Comparison of X-ray Crystallographic Structure, Solution 1H NMR Data, and Molecular Dynamic Simulations of [l-Ala3]DPDPE and [d-Ala3]DPDPE

2. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers;Gardell;J. Neuroscience,2002

3. Conformational restrictions of biologically active peptides via amino acid side chain groups;Hruby;Life Sciences,1982

4. Designing peptide receptor agonists and antagonists;Hruby;Nature Reviews Drug Discovery,2002

5. Emerging approaches in the molecular design of receptor selective peptide ligands: Conformational, topographical and dynamic considerations;Hruby;Biochem. J.,1990

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1. Bifunctional Opioid/Melanocortin Peptidomimetics for Use in Neuropathic Pain: Variation in the Type and Length of the Linker Connecting the Two Pharmacophores;International Journal of Molecular Sciences;2022-01-08

2. CCK2 receptors in chronic pain;Neurobiology of Pain;2022-01

3. Biphalin—A Potent Opioid Agonist—As a Panacea for Opioid System-Dependent Pathophysiological Diseases?;International Journal of Molecular Sciences;2021-10-21

4. Novel hybrid compounds, opioid agonist+melanocortin 4 receptor antagonist, as efficient analgesics in mouse chronic constriction injury model of neuropathic pain;Neuropharmacology;2020-11

5. VF-13, a chimeric peptide of VD-hemopressin(α) and neuropeptide VF, produces potent antinociception with reduced cannabinoid-related side effects;Neuropharmacology;2020-09

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