Experimental evidence that phenylalanine is strongly associated to oxidative stress in adolescents and adults with phenylketonuria

Author:

Sanayama Yoshitami,Nagasaka Hironori,Takayanagi Masaki,Ohura Toshihiro,Sakamoto Osamu,Ito Tetsuya,Ishige-Wada Mika,Usui Hiromi,Yoshino Makoto,Ohtake Akira,Yorifuji Tohru,Tsukahara Hirokazu,Hirayama Satoshi,Miida Takashi,Fukui Mitsuru,Okano Yoshiyuki

Publisher

Elsevier BV

Subject

Endocrinology,Genetics,Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference33 articles.

1. Hyperphenylalaninemia: phenylalanine hydroxylase deficiency;Scriver,2001

2. Adult phenylketonuria;Hanley;Am. J. Med.,2004

3. Adults with late diagnosed PKU and severe challenging behaviour: a randomised placebo-controlled trial of a phenylalanine-restricted diet;Lee;J. Neurol. Neurosurg. Psychiatry,2009

4. Animal models of brain dysfunction in phenylketonuria;Martynyuk;Mol. Genet. Metab.,2010

5. Pathogenesis of cognitive dysfunction in phenylketonuria: review of hypotheses;de Groot;Mol. Genet. Metab.,2010

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