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A clinical trial of safety and tolerability for the selective dopamine D1 receptor antagonist ecopipam in patients with Lesch-Nyhan disease

  • Published:2016-04 Issue:4 Volume:117 Page:401-406
  • ISSN:1096-7192
  • Container-title:Molecular Genetics and Metabolism
  • language:en
  • Short-container-title:Molecular Genetics and Metabolism

Author:

Khasnavis Tanya,Reiner Gail,Sommerfeld Barbara,Nyhan William L.,Chipkin Richard,Jinnah H.A.ORCID

Funder

Psyadon Pharmaceuticals

Publisher

Elsevier BV

Subject

Endocrinology,Genetics,Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference42 articles.

1. Manual for ASEBA School-Age Forms & Profiles;Achenbach,2001

2. Manual for ASEBA Adult Forms & Profiles;Achenbach,2003

3. Self-injury in Lesch-Nyhan disease;Anderson;J. Autism Dev. Disord.,1994

4. Cognitive abilities of patients with Lesch-Nyhan disease;Anderson;J. Autism Dev. Disord.,1992

5. Randomized controlled trials of the D1/D5 antagonist ecopipam for weight loss in obese subjects;Astrup;Obesity,2007

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1. Management of neurological symptoms in Lesch-Nyhan disease: A systematic review;Neuroscience & Biobehavioral Reviews;2024-10

2. Description of the Molecular and Phenotypic Spectrum of Lesch-Nyhan Disease in Eight Chinese Patients;Frontiers in Genetics;2022-04-26

3. Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders;Nature Communications;2021-06-09

4. Purine and Pyrimidine Metabolism;Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics;2021

5. Neurobiology of Self-Injurious Behavior;Self-Injurious Behavior in Individuals with Neurodevelopmental Conditions;2020
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