Human microsomal cyttrochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and its intestinal absorption and metabolism in rat

Author:

Wu Lili,Zhong Wanping,Liu Junjin,Han Weichao,Zhong Shilong,Wei Qiang,Liu Shuwen,Tang Lan

Funder

Foundation for Distinguished Young Teachers in Higher Education of Guangdong

Foundation for graduate education innovation project of Guangdong

Foundation of science and technology of Guangdong

Program for Pearl River New Stars of Science and Technology in Guangzhou

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,General Medicine

Reference33 articles.

1. Thalidomide metabolism by the CYP2C subfamily;Ando;Clin. Cancer Res.,2002

2. HPLC-electrospray ionization ion trap tandem mass spectrometry analysis of oxymatrine and its metabolites in rat urine;Chen;Yao Xue Xue Bao,2005

3. ADAPT II User's Guide: Pharmacokinetic/pharmacodynamic Systems Analysis Software;D' Argenio,1997

4. (+)-12alpha-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens;Ding;Bioorg. Med. Chem. Lett.,2006

5. Pharmacokinetic–pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition;Dresser;Clin. Pharmacokinet.,2000

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3