On-line characterization of monoclonal antibody variants by liquid chromatography–mass spectrometry operating in a two-dimensional format

Author:

Alvarez Melissa,Tremintin Guillaume,Wang Jennifer,Eng Marian,Kao Yung-Hsiang,Jeong Justin,Ling Victor T.,Borisov Oleg V.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference37 articles.

1. Heterogeneity of monoclonal antibodies;Liu;J. Pharm. Sci.,2008

2. Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods;Vlasak;Curr. Pharm. Biotechnol.,2008

3. Heterogeneity of recombinant antibodies: linking structure to function;Harris;Dev. Biol. (Basel),2005

4. Identification of multiple sources of charge heterogeneity in a recombinant antibody;Harris;J. Chromatogr. B,2001

5. Stability of protein pharmaceuticals;Manning;Pharm. Res.,1989

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