Redox and detox: Malate shuttle metabolism keeps exhausted T cells fit
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Physiology
Reference8 articles.
1. CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer;McLane;Annu. Rev. Immunol.,2019
2. The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate;Weisshaar;Nat. Immunol.,2023
3. Impaired nicotinamide adenine dinucleotide (NAD(+) ) metabolism in diabetes and diabetic tissues: Implications for nicotinamide-related compound treatment;Fan;J. Diabetes Investig.,2020
4. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen;Vardhana;Nat. Immunol.,2020
5. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion;Scharping;Nat. Immunol.,2021
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