A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline-Reference-Cited by-同舟云学术

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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

Published:2018-05 Issue:5 Volume:27 Page:1081-1095.e10
ISSN:1550-4131
Container-title:Cell Metabolism
language:en
Short-container-title:Cell Metabolism

Author:

Tarragó Mariana G.,Chini Claudia C.S.,Kanamori Karina S.,Warner Gina M.,Caride Ariel,de Oliveira Guilherme C.,Rud Micaela,Samani Adrienne,Hein Kyaw Z.,Huang Runqing,Jurk Diana,Cho Dong Seong,Boslett James J.,Miller Jordan D.,Zweier Jay L.,Passos João F.,Doles Jason D.,Becherer David J.,Chini Eduardo N.

Funder

Ted Nash Long Life Foundation

the Glenn Foundation for Medical Research

Calico Laboratories

Mayo Foundation

NIH

BBSRC

MRC Arthritis UK

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Physiology

Reference62 articles.

1. Regulation of intracellular levels of NAD: a novel role for CD38;Aksoy;Biochem. Biophys. Res. Commun.,2006

2. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation;Bai;Cell Metab.,2011

3. The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease;Bai;Cell Metab.,2012

4. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice;Baker;Nat. Genet.,2004

5. Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity;Bakondi;Free Radic. Biol. Med.,2011

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