Effects of KE-758; an active metabolite of the new anti-rheumatic drug KE-298, d-penicillamine, bucillamine and auranofin on the proliferation of murine lymphocytes, and the production of nitric oxide by murine macrophages

Author:

Inoue Tomoyuki,Takeshita Kimiyo,Fukushima Kiyomi

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference23 articles.

1. A 16-week dose finding double blind study of KE-298, a newly developed novel DMARD, in patients with rheumatoid arthritis;Abe;Proc. XIXth ILAR Congress Rheum.,1997

2. Pharmacological profile of KE-758, the main metabolite of the antirheumatic agent KE-298;Yasuda;Drugs Exp. Clin. Res.,1996

3. Suppressive effect of a new anti-rheumatic drug KE-298 on TNF-α-induced matrix metalloproteinase production in RA synoviocytes;Takahashi;Drugs Exp. Clin. Res.,1998

4. Mechanisms of KE-298, 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid, to suppress abnormal synovial cell functions in patients with rheumatoid arthritis;Sakane;J. Rheumatol.,1997

5. Effect of KE-298 on experimental arthritis in mice;Nagai;Pharmacology,1996

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