Identification of a cytochrome P450 from Tripterygium hypoglaucum (Levl.) Hutch that catalyzes polpunonic acid formation in celastrol biosynthesis

Author:

CHEN Xiao-Chao,LU Yun,LIU Yuan,ZHOU Jia-Wei,ZHANG Yi-Feng,GAO Hai-Yun,LI Dan,GAO Wei

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,General Medicine

Reference39 articles.

1. Total alkaloids of Tripterygium hypoglaucum (levl.) Hutch inhibits tumor growth both in vitro and in vivo;Jiang;J Ethnopharmacol,2014

2. Research progress on chemical composition and activity of THH;Zhang;Appl Chemi Ind,2016

3. Deciphering the active ingredients and molecular mechanisms of Tripterygium hypoglaucum (Levl.) Hutch against rheumatoid arthritis based on network pharmacology;Jiang;Evid Based Complement Alternat Med,2020

4. Antifertility effects of crude ethanol extracts of Tripterygium hypoglaucum (Levl.) Hutch in male Mongolian gerbils (Meriones unguiculatus);Wang;J Adv Res,2011

5. A metabolomics study on the immunosuppressive effect of Tripterygium hypoglaucum (Levl.) Hutch in mice: the discovery of pathway differences in serum metabolites;Guo;Clin Chim Acta,2018

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