A novel approach to the site specific delivery of potential HMG-CoA reductase inhibitors

Author:

Menear Keith A.,Patel Dilip,Clay Valerie,Howes Colin,Taylor Peter W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Lipid Research Clinics Program;The Lipid Research Clinics Coronary Prevention Trial Results: I. Reduction in incidence of coronary heart disease. JAMA,1984

2. Pooling Research Group;Final report of the pooling project. J. Chronic Dis.,1972

3. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 6. trans-6-[2-(Substituted-1-naphthyl)ethyl(or ethenyl)]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones

4. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

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