Synthesis of hybrid distamycin–cysteine labeled with 99mTc: a model for a novel class of cancer imaging agents

Author:

Baraldi Pier Giovanni,Romagnoli Romeo,Duatti Adriano,Bolzati Cristina,Piffanelli Adriano,Bianchi Nicoletta,Mischiati Carlo,Gambari Roberto

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. (a) Arcamone, F.; Orezzi, P. G.; Barbieri, W.; Nicolella, V.; Penco, S. Gazz. Chim. Ital. 1967, 97, 1097.

2. (b) Arcamone, F.; Penco, S.; Orezzi, P. G.; Nicolella, V.; Pirelli, A. Nature 1964, 203, 1064. For the biological activities of distamycin

3. A see: (c) Hahn, F.E. in Antibiotics III: Mechanism of action of antimicrobial and antitumor agents; Corcoran, J. W.; Hahn, F. E. Eds.; Springer Verlag: New York, 1975, 79.

4. (d) Bialer, M. In Antiviral Drugs and Interferon; The molecular basis of their activity, Becker, T., Ed.; Martinus Nijoff: Boston, 1984; p 143.

5. Crystal structures of the side-by-side binding of distamycin to AT-containing DNA octamers d(ICITACIC) and d(ICATATIC)

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