Author:
Hoemann Michael Z.,Kumaravel G.,Xie Roger L.,Rossi Richard F.,Meyer Sylvia,Sidhu Alban,Cuny Gregory D.,Hauske James R.
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference12 articles.
1. Recent Developments in Antibacterial Research
2. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility
3. Solid-phase synthesis of substituted quinoline and isoquinoline derivatives using heterocyclic N-oxide chemistry
4. See ref 3 for experimental detail.
5. All reagents and chemicals were purchased from Aldrich, Lancaster, Advanced Chemtech, Novabiochem and/or Fluka. 1H NMR and 13C NMR spectra were obtained on a Varian 300MHz spectrometer. Chemical shifts are reported in ppm relative to DMSO (2.53ppm for 1H and 39.52ppm for 13C). Mass spectrometry data were obtained on a Micromass Platform LC. Final compounds were purified by preparatory HPLC (C-18, MeCN:H2O 70:30 with 0.5% TFA) and lyophilized to amorphous solids.
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